Tangeretin Ameliorates Podocyte Injury Through Blocking Epithelial to Mesenchymal Transition in High Glucose-exposed Podocytes and Diabetic Kidneys (P06-009-19)
نویسندگان
چکیده
منابع مشابه
Erythropoietin ameliorates podocyte injury in advanced diabetic
26 Podocyte damage and accumulation of advanced glycation end-products (AGEs) are 27 characteristic of diabetic nephropathy (DN). The pathophysiology of AGE-challenged 28 podocytes such as hypertrophy, apoptosis and reduced cell migration is closely 29 related to the induction of cell cycle inhibitor p27 and to the inhibition of neuropilin 30 1 (NRP1). We previously demonstrated that treatment ...
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The dipeptidyl peptidase-4 (DPP-4) inhibitor saxagliptin has been found to reduce progressive albuminuria, but the exact mechanism of inhibition is unclear. Podocyte epithelial-to-mesenchymal transition (EMT) has emerged as a potential pathway leading to proteinuria in diabetic nephropathy (DN). Stromal cell-derived factor-1α (SDF-1α), one of the substrates of DPP-4, can activate the protein ki...
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ژورنال
عنوان ژورنال: Current Developments in Nutrition
سال: 2019
ISSN: 2475-2991
DOI: 10.1093/cdn/nzz031.p06-009-19